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Description
Formally, TRXR can be described as an oxidoreductase that relies on NADPH and FAD to reduce TRX-S2
The human liver can produce it, and it is also present in several foods
Eur J Endocrinol (2021) 185(4):G43g67
Biomaterials 140 , 7987 (2017)
Absent Fn3K, NRF2 is glycated, a post-translational modification which enhances KEAP1-driven degradation, impairs NRF2 binding to transcriptional cofactors sMAF, reduces NRF2 binding in the promoter region of target genes, and leads to reduced transcription of canonical NRF2 pathway genes [87]
It is estimated that about 30% of the global population is affected by nonalcoholic fatty liver disease
