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finally, (5) mitosomes represent a type of MRO incapable of energy production, as they lack the components of an active electron chain and mostly have lost their genome [1, 5]

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However, its therapeutic application is often limited by poor permeability as it is a P-glycoprotein (P-gp) efflux substrate, low aqueous solubility ( 500 mg/kg/day) may increase risks of kidney calculus, skin irritation, chronic anemia, and even drug-induced liver damage [83]