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In liver-specific Drp1 knockout mice, a marked reduction in mitochondrial respiration was observed, associated with increased lipid accumulation [76]

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doi: 10.18632/aging.102944

The pathology proceeds through different stages: from simple hepatic steatosis, it progresses toward non-alcoholic steatohepatitis (NASH), fibrosis, cirrhosis and in the most severe cases, toward hepatocellular carcinoma (HCC) [79]

In healthy cells, about 90% of glutathione is in its active form, with only 10% in its oxidized state