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Pemetrexed, a clinically applied multi-target antifolate cytotoxic chemotherapeutic drug, has been effective in treating breast cancer and metastatic breast cancer patients previously treated with anthracycline or taxane, with lower toxicity levels (Zhou et al., 2015)

In vivo characterization has empirically confirmed this spatial restriction, showing that the AND gate circuit tightly restricts expression of the therapeutic gene to the TME and remains off in healthy organs, leading to a dramatic decrease in off-target toxicity

Stephen Thomas, MD: Over the six years we've been dealing with this thing, at some points in time, it has happened very, very quickly, not even years but quarters, months, there have been changes

Kelemen LE

Arvat, E., Gianotti, L., Di Vito, L., Imbimbo, B

In many cardiovascular diseases appear inappropriate mitochondrial fission and Drp1 upregulation, such as heart failure, myocardial infarction and cardiac hypertrophy