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Although IFN- is not one of the three most frequently implicated proinflammatory cytokines in OA, its role in ferroptosis regulation warrants attention

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Since many metabolic pathways result in a decrease in GSH and an increase in GSSG concentrations, the restoration of reduced glutathione is crucial for maintaining cellular homeostasis

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These include developmental disorders, neurodegenerative diseases, neuroimmune and metabolic conditions, as well as affective and behavioral syndromes (Zhang et al., 2021d