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KCNN3 has ion channel activity, which can bind calmodulin to form cell membrane tissue components, participating in ion transport (including K + ions), synaptic transmission [10], development and growth of nerve cells [11], and calcium activation of potassium channel activity [12]

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In addition, intestinal epithelial cells (IECs), otherwise known as enterocytes, are adjoined by TJ complexes that are further tethered to an intracellular cytoskeleton permitting communication across the epithelium and regulating processes including the cell cycle (Brenchley and Douek 2012)

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