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12 Other studies have now shown high levels of TMAO are associated with high levels of creatinine, low levels of HDL, type 2 diabetes and kidney disease 13

Therefore, carnitine is essential as fuel for muscles, and more than 95% of the total body carnitine is found in skeletal muscle

Our observations further support Di Marzo et al

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Ott P, Clemmesen O, Larsen FS (2005) Cerebral metabolic disturbances in the brain during acute liver failure: from hyperammonemia to energy failure and proteolysis

Therefore, transporters located in organelle membranes must operate to fulfill the intracellular traffic of carnitine and its derivatives