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A significant upregulation of mucosal IL23p19 , IL23R and IL17A expression was detected in patients who did not respond to anti-TNF- therapy, in association with elevated number of mucosal T cells which expressed both TNFR2 and IL-23R and demonstrated high expression of inflammatory genes and resistance to apoptosis [172]

Source: Gasperi V, et al., 2019, International Journal of Molecular Sciences , "Niacin in the Central Nervous System" NAD+ Decline and Aging (2015): Landmark aging research identified NAD+ depletion as a driver of multiple aging hallmarks including mitochondrial dysfunction, impaired DNA repair, metabolic problems, and neurodegeneration

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All amplifications were carried out in triplicate for each RNA sample and primer set