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Quantitative measurement of selected metabolites in cultured cells The relative levels of selected metabolites (NA, SAM, SAH, NAD + ) regulated by cellular energy expenditure pathways associated with NNMT were simultaneously detected using LC/MS/MS and MRM ratios

Sampson CM, Dimet AL, Neelakantan H, et al

Those who dont consume any type of animal product including dairy, Vegans, are prone to vitamin B12 deficiency unless they take specific measures to supplement or consume fortified food products

"Nicotinamide N-methyltransferase knockdown protects against diet-induced obesity." Nature

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But the mechanism is well-characterized and the target (NNMT in adipose tissue) is a legitimate pathway for visceral fat reduction