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Description
Injectable peptides bypass the digestive system and may enter systemic circulation intact, creating important questions about dosing, absorption, half-life, receptor effects, off-target effects, and long-term safety

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Hemoglobin concentrations (mmol/L) of ARA 290 patients compared with placebo were 8.9 0.21 (standard error of the mean [SEM]) versus 8.6 0.26 at baseline and 8.7 0.19 versus 8.7 0.34 at the end of dosing on wk 4

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To address this gap, we propose the concept of a Dynamic Living Digital Twin framework for precision dosing in critical illness

A review of the common neurodegenerative disorders: current therapeutic approaches and the potential role of nanotherapeutics
