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In vivo dosing relies largely on intraperitoneal administration and exposure profiles that differ from oral human use, and interspecies differences in mitragynine metabolism and elimination complicate dose extrapolation

Philpot BD, Sekhar AK, Shouval HZ, Bear MF (2001)

European Spine Journal Official Publication of the European Spine Society, the European Spinal Deformity Society, and the European Section of the Cervical Spine Research Society 29 (7), 16491659

Adding too much or too little BAC water

Recent trial of proplylactic treatment with T 4 (1.0 ~ 2.0g/Kg/day) for one year in euthyroid patients with Hashimoto's thyroiditis showed decrease of anti-TPO antibodies and thyroid B-lymphocytes(105), suggesting prophylactic T 4 therapy might be useful to stop progression of disease

& Brose, N