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The drug may also act as a putative ligand for adenine nucleotide translocator (exports ATP from the mitochondrial matrix and imports ADP into the matrix) that triggers apoptosis

In this case, brightness ( L * values) decreased, redness ( a * values) increased, and yellowness ( b * values) decreased

Mamoudou, H., & Mune, M

Furthermore, NINJ1 appears to play a role in the later stages of ferroptotic cell death processes (cell lysis/LDH release) [33] and is dispensable for initial steps such as lipid peroxidation, channel-mediated calcium influx, and cell swelling [35]

Neopterin release and tryptophan degradation in patients with uveitis

This suggests that mitochondria by itself integrate the enzymatic machinery to properly regulate ceramides and assist its biological activity potentially by its interaction to ER