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A significant increase in the intracellular Ca 2+ influx was observed in 3T1AM-exposed immortalized human CECs, suggesting that 3T1AM-type analogs should be used as the leading compounds in developing drugs that would directly activate TRPM8 and reduce desiccation of the anterior ocular surface epithelia [35]

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In the ALF group, the levels of ALT, AST, ALP and GGT were significantly higher than those in the other two groups