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however, the most recent version of definition may be imbalance between oxidants and antioxidants in favor of the oxidants, leading to a disruption of redox signaling and control and/or molecular damage (Sies, 2018)

This phenotype was commonly observed in aggressive tumor subtypes that include radiation treatment in current therapy regimens, such as non-small cell lung cancer (NSCLC) and glioblastoma (GBM) brain tumors