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When nerves are damaged due to medical conditions like diabetes, treatments like chemotherapy, or natural deterioration of muscles and nerves over time, it can lead to nerve pain

Irinotecan has shown limited efficacy due to low BBB penetration

D-carnitine supplementation has been found to induce liver inflammation, oxidative stress, and apoptosis in animal studies (13)

Since a comprehensive presentation of all therapies would be too verbose, we will focus on a selection of natural products, such as resveratrol, curcumin, berberine, quercetin, and clinical drugs that have been extensively investigated in different pathological models (Table 1)