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8 Conclusion and future perspectives The recognition of ferroptosis as a critical mechanistic link between dysregulated metabolism, immune activation, and chronic airway inflammation establishes the Ferroptosis-Immune-Metabolic Axis as a transformative conceptual framework for understanding asthma pathogenesis

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4.1.2 Iron overload promotes joint ferroptosis by disrupting gut barrier Imbalanced host iron homeostasis remodels the structure of the gut microbiota, which can be manifested as changes in alpha-diversity, alterations in taxonomy composition and community dominance (Mao et al., 2024)