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Phase 3: Optimize both (weeks 9-16) Increase AOD 9604 to 300-500mcg daily based on tolerance

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In folate deficiency, THF levels are low

The GRAS determination was likely based on the compound's limited systemic absorption (when ingested), short plasma half-life, and lack of acute toxicity signals in the Phase 2b obesity trial

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AOD 9604 failed to achieve regulatory approval after early trials, and retatrutide remains in Phase 3 development without NICE or MHRA guidance