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References 1 Nature Medicine (2014)Nicotinamide N-methyltransferase knockdown protects against diet-induced obesity (preclinical)

01 Bring the vial to room temperature Take the vial out of the freezer and let it sit on the counter for 15 to 20 minutes

50mg produces approximately 4050% enzyme inhibition, while 100mg achieves 6075% inhibition, but the curve plateaus beyond 150mg, suggesting diminishing returns

Reiten OK, et al

"Structure-Activity Relationship for Small Molecule Inhibitors of Nicotinamide N-Methyltransferase." Journal of Medicinal Chemistry

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