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To further assess the severity of iron deficiency, additional markers like transferrin saturation (TSAT, the percentage of the plasma protein transferrin that is bound with iron, which is decreased with deficiency) may be used

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In this context, some of the new formulations of adalimumab have removed or substantially lowered the concentration of the citrate buffer to a residual concentration of 1.2 mM [43, 44], which should minimize or prevent pain potentially associated with this buffer

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They were treated with antihistamines and steroids