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What they found: Mean weight loss: 2.6 kg vs 2.3 kg placebo , a difference of only 0.3 kg (1 %) Statistically non-significant Clinically unsatisfactory for the obesity indication Safety profile remained favorable Why it matters: The study stopped the development of AOD-9604 as a drug

[2] Since the vitamin B12 precursor cobinamide is a scavenger of nitric oxide, researchers wanted to see if vitamin B12 would be helpful for psoriasis as well

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Reactions are more likely during the intensive loading phase simply because the doses are close together

Pollard, J

Improved gut healthand healing of GI issues