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Pep4 is a selected fragment of SLPI (Secretory Leucocyte Protease Inhibitor), whereas Pep4M is a modified form in which the highly reactive cysteine residues were replaced with less reactive methionine residues

Phase I clinical trials using NSC-mediated OV delivery (NSC-CRAd-S-pk7) in GBM patients have demonstrated enhanced safety and efficacy with minimal toxicity

Its ability to protect nerve cells in the brain could offer new ways to treat brain injuries or neurodegenerative diseases

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