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Valproic acid may be especially useful in older patients due to its low risk of hypotension, respiratory depression, or sedation
Moreover, biodistribution and in vivo gene editing studies in female Ai9 mice following systemic administration revealed that LNPs primarily accumulated in the liver, spleen, and lungs, where they achieved effective gene knockout with minimal toxicity [131]

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We then sought to distinguish between cell-mediated responses to viral entry and innate recognition and to determine if DC restructure glycolysis equally with activating stimuli or tailor it in response to IAV infection

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10.1039/c8fo00168e 16 DengY.WangL.YangY.SunW.XieR.LiuX.et al (2013)
