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SARS-CoV-2 structural proteins are known to harbor a numerous post-translational modifications (PTMs), including phosphorylation, glycosylation, and ubiquitination

This results in a variable onset of neurodegeneration, with typical moderate to severe neurodegeneration evident at approximately 12 months of age

FDA, 2024.

Hypertension 68 , e67e94 (2016)

This highlights age as a significant risk factor for non-healing, a reality that can feel discouraging

doi: 10.1002/pul2.12357 Summary Keywords heme oxygenase 1, ferroptosis, vascular dementia, oxidative stress, lipid peroxidation Citation Zou X, Cai L, Zhang J, Yuan Y, Song J, Hu Z, Ruan X, Peng R and Zhang X (2025) Mechanism of heme oxygenase-1 regulation of ferroptosis in vascular dementia