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381 Both SIRT2-catalyzed deacetylation and SIRT5-mediated desuccinylation of PKM2 reduce the activity of PKM2, preventing the carbon entry into the TCA cycle

For example, if you take 100mg of a drug with a 4-hour half-life, after 4 hours you'll have approximately 50mg remaining, after 8 hours about 25mg, and so on

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