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A small trial compared the serum/blood levels of metabolites in arterial and jugular venous blood to indirectly assess metabolite uptake into the brain [50]

Development of acute tolerance during exposure of hippocampal explants to an opioid peptide

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Five liver samples (200 mg each) were spiked with either 50, 100, 200, 300, or 400 M GSH prior to extraction

doi: 10.1016/j.aca.2021.338873

Today, targeted gene tests make it possible to diagnose exactly where the methylation cycle is interrupted and thus enable specific therapy with the corresponding nutrients