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Nature Hong et al

It has an improved ability to inhibit the enzymatic activity of NNMT and drastically reduces the formation of MNAM

The peptide has shown a generally favorable safety profile, with most adverse events being mild and transient

(2000) AJP-Endocrinol Metab ex vivo human/rodent adipose assays

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The compound shows high enzymatic selectivity, preserves lean mass, and engages longevity-related pathways (e.g., SIRT1), but remains a nonFDA-approved research substance that is WADA-banned and should be used under medical guidance