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If this period does not improve liver function and/or decrease episodes of decompensation, a liver transplant can be considered

Harnessing TRAIL-induced cell death for cancer therapy: A long walk with thrilling discoveries

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The proposed pathomechanisms include the hyperglycemia-induced elevated sorbitol and glucosamine pathway, dysregulated glycolysis, and mitochondrial oxidative phosphorylation in diabetic nerve tissues leading to mitochondrial dysfunction and oxidative stress [46]

Experiments were repeated two to three times independently with similar results

doi: 10.1016/j.cell.2012.03.042 35 DongH.XiongL.ZhuZ.ChenS.HouL.SakabeT
