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and lysine 6, lysine 12, and lysine 16 of histone H4 (H4K6, H4K12, and H4K16) ( Non-Histones SIRT1-driven deacetylation of multiple non-histone proteins has been shown to impact pathophysiological processes such as cell differentiation ( Regulation of SIRT1 Expression SIRT1 expression is subject to many layers of regulation, including at the transcriptional and post-transcriptional ( Table 1 and Figure 3 )

Endocrinology and metabolism

PloS One 7 (10)

Gclc f/f mice were generated as described 30 and crossed with the Rosa26-CreERT2 mouse strain (Jackson Labs, #008463) or Nrf2 f/f mouse strain (Jackson Labs, #025433)

[DOI] [PubMed] [Google Scholar] Casas AI, Dao VT, Daiber A, Maghzal GJ, Di Lisa F, Kaludercic N, Leach S, Cuadrado A, Jaquet V, Seredenina T, Krause KH, Lpez MG, Stocker R, Ghezzi P, Schmidt HH