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This action of melatonin against apoptosis is crucial in various tissues for survival and has even been used in experimental treatments for organ transplants because it protects the tissue against ischemia and reperfusion injuries [4,8,22,23,24,25,26,27,28,29,33,34,35,36,37,38,39,40]

For the best results, a series of treatments may be recommended, typically spaced a week or two apart

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[DOI] [PMC free article] [PubMed] [Google Scholar] Pattni B.S., Chupin V.V., Torchilin V.P

As with anything related to your health, you should always feel comfortable to ask questions about any prescribed or over-the-counter medication