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Thus, these non-specific effects may limit their in vivo applicability

Since the isolation of the cDNA in 1994, the work on the mammalian Molecular Biology of Methylenetetrahydrofolate Reductase (MTHFR) and Overview of Mutations/Polymorphisms MTHFR gene has resulted in significant advances in our understanding of its genomic organization, genetic variations and involvement in human disorders

However, B12 levels can rise regardless of whether treatment is effective

Animal studies and case reports were excluded

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