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Diagnosis The mean age of diagnosis is approximately 14 months [1, 2]

Emoxypine and its succinate derivative have shown promising effects in the management of several neurodegenerative diseases (such as Alzheimer's, Parkinson's, and Multiple sclerosis), and the proposed mechanism of action was the inhibition of prooxidants in the mitochondria (Litvinenko et al., 2019)

Moreover, the endogenous GSH pool is far too low to detoxify exogenous SF completely suggesting that reversible GSH conjugation is an inefficient detoxification mechanism in the presence of high ITC concentrations

P.IvanovD.AdamJ

Alteration of such ratio during oxidative burst can modulate redox signaling pathways related to various cellular processes including proliferation, growth and apoptosis [1]

2023;120(10):e2206758120