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Description
doi: 10.1038/s41582-022-00648-3
C57BL/6J wild-type (WT) mice were purchased from Jackson Laboratory (Bar Harbor, ME)

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RIP3 siRNA Knockdown Transient genetic silencing of RIP3 was performed by reverse transfection of RAW264.7 cells with 2030 Nm Silencer Select siRNAs (Life Technologies, Inc.) using Lipofectamine RNAiMax reagent (Life Technologies, Inc.), and Opti-MEM medium (Life Technologies, Inc.)

Author contributions DG and LMZ were responsible for animal care, breeding, and sampling
Nuclear receptors such as peroxisome proliferator-activated nuclear receptors (PPAR) play a key role in hepatic lipid metabolism, however results on association of PPAR and severity of NAFLD have been variable (75)