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MTAP deletions in cancer create vulnerability to targeting of the MAT2A/PRMT5/RIOK1 axis

Summary Keywords amodiaquine, quinoneimine, cytotoxicity, endoplasmic reticulum stress, human glutathione S -transferases P1 Citation Zhang Y, den Braver-Sewradj SP, den Braver MW, Hiemstra S, Vermeulen NPE, van de Water B, Commandeur JNM and Vos JC (2018) Glutathione S -Transferase P1 Protects Against Amodiaquine Quinoneimines-Induced Cytotoxicity but Does Not Prevent Activation of Endoplasmic Reticulum Stress in HepG2 Cells

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Cell Death Differ 8:11311133 Ribeil JA, Zermati Y, Vandekerckhove J et al (2007) Hsp70 regulates erythropoiesis by preventing caspase-3-mediated cleavage of GATA-1

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These enzymes neutralize superoxide radicals and hydrogen peroxide, reducing oxidative burden