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In both Phase 1 and Phase 2 of the study, there was a statistically significant (p=0.0003 in Phase 1 and p=0.02 in Phase 2) decrease in the mean prolactin (17.9924.76 ng/mL in Phase 1 and 19.6123.42 ng/mL in Phase 2) in the pooled samples (Group 5) in comparison to the mean prolactin (19.6727.69 ng/mL in Phase 1 and 21.0625.06 ng/mL in Phase 2) of the serum collected at 0 h (Group 1)

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Mechanistically, stabilization of wild-type p53 and induction of the p53 target gene CDKN1A (p21) leads to decreased expression of the ribonucleotide reductase (RNR) subunits RRM1 and RRM2