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Pred-skin: a web portal for accurate prediction of human skin sensitizers
Keating SE, Zaiatz-Bittencourt V, Loftus RM, Keane C, Brennan K, Finlay DK, et al
The non-metabolized part can limit the availability of pyrimidines for DNA synthesis and end up causing uracil incorporation into DNA, which results in double-stranded breaks and cell death
Moreover, sensor protein was stabilized at physiological pH in TBS buffer (Fig
