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4l) and increased creatine levels in iWAT (Extended Data Fig

Among them, caspase-3 is closely related to apoptosis and is activated by both intrinsic and extrinsic pathways, making it a focus for cancer therapy ( In addition to the above mentioned, small molecule prodrugs that can be activated by other kinds of enzymes have also been developed (Zhang H

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Downregulation of protein kinase C by phorbol ester treatment abolishes the synergistic effect of AVP on ACTH release by CRH (68)

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Notably, we observed lower levels of tissue coenzyme A (CoA), which has been considered to be extremely stable 10 , resulting in reduced mitochondrial functionality and metabolic rewiring