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Trans Oncol

Additionally, nuclear GSH contributes to the regulation of cell proliferation by influencing gene expression and epigenetic states 18

Since GSH is an important storage form of reduced sulfur in cells, high demands for GSH due to metal stress stimulate sulfate uptake, reduction and assimilation in order to meet the needs of cysteine for GSH and PC biosynthesis [28,29]

Enzyme localization, properties, and functions The enzymes of the ascorbateglutathione cycle are localized in different intracellular compartments (Table 1)

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GST binds the substrate at the hydrophobic H-site of the enzyme and GSH at the hydrophilic G-site which together form the active site of the enzyme (see Figure 6)