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For example, senescent fibroblasts no longer produce collagen and elastin resulting in a dysfunctional support matrix and skin that is not capable of efficient damage repair

APLN/APLNR signaling has key function in several physiological processes like cardiac function, angiogenesis, metabolism and body fluid homeostasis, and also in pathological conditions like heart failure, cancer, obesity and diabetes (reviewed in detail [175])

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The method according to any one of claims 78-79, wherein said cancer cell is selected from the group consisting of mesothelioma, testicular cancer, endometrial cancer, and subsets of ovarian, pancreatic, and non small cell lung cancers

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