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The de novo synthesis of glutathione requires the consecutive action of two enzymes, -glutamylcysteine synthetase (-GCS) and GSH synthetase [13,33]

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Use with caution in combination with other drugs that prolong the QT interval (4.2, 5.11, 7.7, 7.8) Use In Specific Populations Pregnancy: SSRI use, particularly later in pregnancy, may increase risk for persistent pulmonary hypertension and symptoms of poor adaptation (respiratory distress, temperature instability, feeding difficulty, hypotonia, tremor, irritability) in the neonate (8.1) Pediatric Use: Safety and effectiveness of PROZAC in patients 65 years of age) did not differ significantly from that in younger normal subjects

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Low CuCl 2 concentrations (0.2-0.2.4mmol/l) did not induce significant differences, while higher concentrations (0.61.6.0mmol/l) led to significant toxicity in HepG2 ATP7B-KO cells (Fig