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Studies suggest that the average patient will not get any clinical benefit from T4 therapy until TSH rises above approximately 10 mU/L

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Bolander-gouailleCTreatment of depression: time to consider folic acid and vitamin B12

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In addition, studies also demonstrated that the C677T polymorphism of MTHFR is associated with onset age of schizophrenia in a dose-dependent manner, such as increasing numbers of the mutant T allele is linked with early onset 50
