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3 Zebrafish models for uncovering therapeutic mechanisms of phytochemicals in alcohol-related liver disease Alcohol-related liver disease (ALD), a major healthcare burden stemming from chronic excessive alcohol consumption, progresses through a complex pathogenesis involving metabolic disruption, oxidative stress, and inflammation

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10.4049/jimmunol.1301901 [DOI] [PMC free article] [PubMed] [Google Scholar] 92

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These data are the first demonstration of mitochondrial repair of oxidative DNA lesions being sufficient to protect animals against the adverse outcomes of chronic high-fat diet consumption
