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How does metformin (biguanide oral hypoglycemic agent) cause vitamin B12 deficiency?

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The cells were rocked on a shaker for 2min, the supernatants were collected and measured at 450nm

SORT: KEY RECOMMENDATIONS FOR PRACTICE Pernicious anemia, which is characterized by an autoimmune-mediated chronic atrophic gastritis, is a classically described cause of vitamin B 12 deficiency 2