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It is synthesized in the body from two essential amino acids, lysine and methionine, and is primarily stored in the skeletal muscles, heart, and brain

[PubMed] [Google Scholar] 26.Stefanou M.I., Palaiodimou L., Bakola E., Smyrnis N., Papadopoulou M., Paraskevas G.P., Rizos E., Boutati E., Grigoriadis N., Krogias C., Giannopoulos S., Tsiodras S., Gaga M., Tsivgoulis G

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Pigment incontinence may be present within the papillary dermis

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They can also take the appearance of a red patch that becomes crusty, itchy, or bleeds