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This crucial phase of the malady, in analogy with other viral infections and to a widely accepted pharmacological praxis, should be timely treated either with etiotropic drugs (which in COVID-19 case are still lacking) as well as with host-directed agents to manage/prevent the symptoms (Sestili and Stocchi, 2020)

It has been postulated that Keap1 works as a molecular switch that is capable to turn the Nrf2-signaling pathway on or off according to intracellular redox circumstances

It can be treated with a variety of natural products and bioactive compounds

Urate promotes SNCA/-synuclein clearance via regulating mTOR-dependent macroautophagy

Glucagon also directly enhances hepatic ketone synthesis at the level of gene expression

All four carry 503A compounding status of Under Review as of 2026