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However, the largest Phase IIb trial involving 536 participants failed to demonstrate statistically significant weight loss compared to placebo at the primary 12-week endpoint, leading to development termination in 2007

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doi: 10.1017/S000711451100153X

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So it's really important to get vaccinated, not just to keep you out of the hospital, but also to help limit the amount of spread that can happen in the community