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33,34 Of the Smads, Smad2 and Smad3 have been shown to be the major downstream regulators involved in TGF-1-mediated tissue fibrosis

Immunohistochemistry of GGT1 protein expression in Gclc WT and KO orthotopic and flank tumors (n = 4 animals representative of 2 independent experiments)

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In addition, autophagy appears to have a crucial role in dampening the immune response after irradiation as depletion of key autophagy regulators ATG5 or ATG7, thereby blocking mitophagy, increased cytosolic mtDNA after radiotherapy [110]

Isolation and culture of mouse primary pancreatic acinar cells