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Knockdown of COPZ1 leads to an increase of NCOA4, contributing to the degradation of ferritin, which leads to increased intracellular ferrous iron levels and eventually to ferroptosis

Further research is necessary to delve into the specific regulatory mechanisms of ferroptosis inhibitors and inducers on cell ferroptosis, as well as their effects on autoimmune diseases

Erythropoietic protoporphyria (EPP, defect in ferrochelatase) can result in microcytic RBCs but in one case report of a presumptive congenital form of EPP in a dog, the animal was only mildly or not anemic (Kuntz et al 2020)

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