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doi: 10.1016/j.tips.2018.02.007 128 PhensyA.DriskillC.LindquistK.GuoL.JeevakumarV.FowlerB.et al

this process is characterized by enhanced oxidative stress, mitochondrial structural and functional disorders, and dysregulation between the synthesis and catabolism of chondrocytes (Liu et al., 2024)

The reaction is as follows: Zinc deficiency impairs carbonic anhydrase activity, disrupting carbon dioxide metabolism and affecting energy production and waste removal processes [55, 56]

5d), thus allowing for possible PDHC and OGDC recovery

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Consistent with these results, ZnT8 was significantly upregulated and showed clear co-localization with INS + GCG + cells, with higher ZnT8 intensity in INS + GCG + cells than in INS + GCG cells (Supplementary information, Fig