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Prophylactic treatment of pregnant patients and patients with chronic hemolytic anemias can prevent folic acid deficiency due to the increased requirement for folate in these conditions

The main objective is to suppress menses, thus inducing iatrogenic menopause or pseudopregnancy, which in turn reduces pain symptoms in order to prevent or postpone surgery, which is useful for long-term management of the disease

In overdose, the concentrations of 3-phosphoadenosine 5-phosphosulphate (PAPS) (for sulphation) and glutathione (for cytoprotection) are depleted, and extensive macromolecular binding leads to hepatocellular necrosis

Pyridoxine, B6

B vitamins in stroke prevention: time to reconsider

T-cell immune imbalance in rheumatoid arthritis is associated with alterations in NK cells and NK-like T cells expressing CD38