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Overall, this review enhances our understanding of the molecular mechanisms and therapeutic landscape of copper and cuproptosis in cancer, highlighting the potential of copper- or cuproptosis-based therapies for cancer treatment.

Prior to the development of FOXO4-DRI, research into cellular senescence largely relied on indirect markers of aging, generalized apoptosis pathways, or broad-spectrum senolytic compounds

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One round of DMSA had nearly the same benefit as seven rounds